Semaglutide and tirzepatide are different prescription medications. Both work through hormone pathways involved in appetite, digestion, and blood sugar.
How they work
Semaglutide works through the GLP-1 pathway.
Tirzepatide works through both the GLP-1 and GIP pathways.
These medications are not the same, and people can respond differently to each one.
What may be similar
Both medications:
• Are prescribed based on your individual health history and treatment needs
• May be started at a lower dose and adjusted over time by your provider
• Can have side effects, including digestive side effects
• Require you to follow the instructions that come with your prescription
• Should only be taken as directed by your provider
What may be different
Your provider may consider differences in:
• The medication pathway involved
• Your health history and current medications
• Your treatment goals
• Your response to treatment
• Any side effects or concerns you have
• Availability and prescription requirements
Your treatment plan
There is no single medication that is right for everyone. Your provider decides which medication and dose may be appropriate for your individual needs.
Do not change, stop, or switch your medication without guidance from your provider. If your provider changes your medication or dose, follow the instructions that come with your updated prescription.
Questions about your medication
Message your Care Team through the TrimRx portal if you have questions about your medication, side effects, dose, or treatment plan. Your Care Team can help coordinate next steps with your provider.
Urgent help
Seek emergency care or call 911 if you think you may be having a medical emergency.