Yes, there are some. Not many, and it's worth understanding why they exist.
These medications affect digestion, blood sugar, and appetite. For most people, that's exactly the point. For some people, with certain conditions, it can cause real harm or make an existing problem harder to manage. This list is about safety, not gatekeeping.
What your provider will look at closely
Pregnancy, breastfeeding, or trying to conceive. These medications aren't used during pregnancy or while breastfeeding, so tell your provider if you're planning ahead, it affects timing.
A personal or family history of medullary thyroid cancer, or a condition called Multiple Endocrine Neoplasia type 2 (MEN2). This one is specific, so it's worth asking your family if you're not sure.
Active cancer, or cancer treatment in progress.
End-stage kidney, liver, or heart disease.
A history of pancreatitis or gallbladder problems.
Type 1 diabetes, or a past episode of diabetic ketoacidosis.
A current or past eating disorder. More on this below.
This isn't a pass-or-fail checklist
Your provider reviews everything together — your history, your medications, your goals. Some conditions rule treatment out. Others just mean a different dose, closer monitoring, or a conversation first. That's why a real person reviews every intake instead of a form doing it automatically.
If you're not approved
You'll be told why, and you won't be charged for medication you're not receiving. If your situation changes later — a condition is treated, a medication changes, you finish a course of treatment — you're welcome to apply again.
The most useful thing you can do
Answer everything, including the parts you'd normally skip. Every medication, every supplement, every past diagnosis. It takes a few extra minutes, and it's the difference between your provider making a good decision and making a guess.